· deep learning has advanced the design of static protein structures, but the controlled conformational changes that are hallmarks of natural signaling proteins have remained … · continuous adult hippocampal neurogenesis is involved in memory formation and mood regulation but is challenging to study in humans. Programmable gene integration in human cells has the potential to enable mutation-agnostic treatments for loss-of-function genetic diseases and facilitate many applications in the life … · chimeric antigen receptor (car) t cell therapies have transformed treatment of b cell malignancies. · the gut microbiota is known to be associated with a variety of human metabolic diseases, including metabolic dysfunction–associated steatohepatitis (mash). · present vision restoration technologies have substantial constraints that limit their application in the clinical setting. In this work, we fabricated a subretinal nanoprosthesis using … · directed protein evolution is central to biomedical applications but faces challenges such as experimental complexity, inefficient multiproperty optimization, and local maxima traps. Difficulties finding proliferating progenitor … · science/aaas peer-reviewed journals deliver impactful research, daily news, expert commentary, and career resources. In this work, we report an hlb resistance regulatory circuit in citrus composed of an e3 ubiquitin ligase, pub21, and its … · huanglongbing (hlb) is a devastating citrus disease. · science is the leading multidisciplinary, international journal of peer-reviewed research including analysis and news coverage of breakthroughs and policy. However, their broader application is limited by complex manufacturing …
Science'S Greatest Mystery: Star Survives Supermassive Black Hole
· deep learning has advanced the design of static protein structures, but the controlled conformational changes that are hallmarks of natural signaling proteins have remained...
